Attenuation of Response to Repeated Drug Administration: A Proposal for Differentiating Tachyphylaxis and Tolerance The Journal of Pharmacology and Experimental Therapeutics In the early 2020s, interest in GLP 1 weight loss drugs exploded, said CNN. Now, a new buzzword is taking over: peptides. Once a niche interest among powerlifters and bodybuilders, the injectable substances Ghk Cu Tolerance Desensitization Effectiveness Loss 2021A12 Define the terms tolerance and tachyphylaxis. Discuss the different mechanisms by which tolerance can develop, giving examples where appropriate.